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Canadian Respiratory Journal
Volume 4, Issue 1, Pages 48-51
Case Report

Acute Respiratory Distress Syndrome Associated with Tumour Lysis Syndrome in Leukemia

Chaim M Bell1 and Thomas E Stewart2

1Department of Medicine and Division of Respirology, University of Toronto, Toronto, Ontario, Canada
2Intensive Care Unit, Wellesley-Central Hospital, University of Toronto, Toronto, Ontario, Canada

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute tumour lysis syndrome (ATLS) developed in two patients with acute myelogenous leukemia soon after they were treated with cytosine arabinoside. The patients also developed respiratory distress requiring intubation. Autopsy and clinical findings demonstrated the presence of acute respiratory distress syndrome (ARDS). An association appears to be present between ARDS and ATLS in this group of patients.