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Canadian Respiratory Journal
Volume 8 (2001), Issue 4, Pages 279-282
http://dx.doi.org/10.1155/2001/454835
Case Report

Respiratory Failure Associated with the Lipodystrophy Syndrome in an HIV-Positive Patient with Compromised Lung Function

Natasha Press,1 Valentina Montessori,1 Tony R Bai,2 and Julio Montaner3

1Division of Infectious Diseases, St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
2Division of Respirology, St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
3BC Centre for Excellence in HIV and AIDS, St Paul’s Hospital, Vancouver, British Columbia, Canada

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Protease inhibitors, used as treatment in human immunodeficiency virus (HIV) infection, are associated with a syndrome of peripheral lipodystrophy, central adiposity, hyperlipidemia and insulin resistance. An HIV-positive patient with chronic obstructive pulmonary disease is presented who developed the lipodystrophy syndrome that is associated with the use of protease inhibitors. It is postulated that the lipodystrophy syndrome further compromised his lung function, leading to respiratory failure. Patients who have pulmonary disease and are taking protease inhibitors require monitoring of clinical status and pulmonary function tests.