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Canadian Respiratory Journal
Volume 10, Issue 1, Pages 48-50
http://dx.doi.org/10.1155/2003/612905
Case Report

Sildenafil Treatment of Primary Pulmonary Hypertension

Kevin B Laupland,1,2 Doug Helmersen,2 David A Zygun,1,2 and Sidney M Viner1,2

1Department of Critical Care Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, Canada
2Department of Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, Canada

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 37-year-old woman with primary pulmonary hypertension and worsening symptomatology underwent pulmonary artery (PA) catheterization and vasodilator trials. Oxygen had no effect, but 10 parts/million of nitric oxide reduced mean PA (PAm) pressure by 20%. Prostacyclin infusion at 8 ng/kg/min decreased the PAm pressure by 11%, but further dose increases were limited by systemic hypotension. Sildenafil in doses of 25 mg or higher resulted in an average decrease of 14% in PAm pressure. Sildenafil is a potentially useful treatment option for patients with primary pulmonary hypertension, and further investigation is warranted.