Canadian Respiratory Journal

Canadian Respiratory Journal / 2003 / Article

Original Article | Open Access

Volume 10 |Article ID 792917 |

Cara F Dosman, Peter C Zuberbuhler, Joan I Tabk, Richard L Jones, "Effects of Positive End-Expiratory Pressure on Oscillated Volume during High-Frequency Chest Compression in Children with Cystic Fibrosis", Canadian Respiratory Journal, vol. 10, Article ID 792917, 5 pages, 2003.

Effects of Positive End-Expiratory Pressure on Oscillated Volume during High-Frequency Chest Compression in Children with Cystic Fibrosis


OBJECTIVE: To investigate the effects of positive end-expiratory pressure (PEEP) on end-expiratory lung volume (EELV) and mean oscillated volume (Vosc) during high frequency chest compression (HFCC).DESIGN: A clinic-based prospective intervention study.SETTING: Pulmonary function laboratory, University of Alberta, Edmonton, Alberta.POPULATION: Nine children with cystic fibrosis with little or no obstructive airway disease who were selected from the outpatient Cystic Fibrosis and Pediatric Pulmonary Clinics at the University of Alberta Hospital, Edmonton, Alberta.METHODS: Each child received HFCC alone (at 10 Hz with chest wall pressure of 8 cm H2O) and HFCC plus PEEP. A closed circuit spirometry system was used to measure HFCC- and PEEP-induced changes in EELV, expressed as per cent baseline functional residual capacity (FRC) measured using helium dilution. An isothermic chamber permitted measurement of Vosc.RESULTS: HFCC caused a significant 9% decrease in EELV. Adding 2.0±0.3 cm H2O of PEEP increased EELV back to at least the FRC level. With HFCC alone, Vosc was significantly lower during spontaneous expiration than during spontaneous inspiration, but adding PEEP to HFCC increased Vosc, especially during spontaneous expiration.CONCLUSIONS: Adding PEEP during HFCC prevents the decrease in EELV and increases Vosc. Therefore, PEEP may improve HFCC-induced mucus clearance in children with cystic fibrosis.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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