Canadian Respiratory Journal

Canadian Respiratory Journal / 2004 / Article

Case Report | Open Access

Volume 11 |Article ID 327431 |

SL Aaron, E Wong, D Tyrrell, M Duggan, E Vallieres, L Jewell, B Romanowski, "Interferon Treatment of Multiple Pulmonary Malignancies Associated with Papilloma Virus", Canadian Respiratory Journal, vol. 11, Article ID 327431, 4 pages, 2004.

Interferon Treatment of Multiple Pulmonary Malignancies Associated with Papilloma Virus


Over a period of four years, beginning in spring 1988, a previously healthy man developed a primary squamous cell carcinoma of the tonsil, treated with radiotherapy, followed by 10 distinct, primary bronchial squamous cell carcinomas. Four of the cancers were surgically resected, all of which were positive by hybridization for human papilloma virus (type 16). Following the institution of alpha interferon, three smaller lesions disappeared and a larger one shrank in size, facilitating surgical resection. Over the following seven years no new ones have appeared. The finding of papilloma virus in malignancies should prompt consideration of antiviral therapy.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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