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Canadian Respiratory Journal
Volume 11, Issue 5, Pages 359-362
http://dx.doi.org/10.1155/2004/341942
Case Report

Asbestos and Probable Microscopic Polyangiitis

George S Rashed Philteos,1 Kelly Coverett,1 Rajni Chibbar,2 Heather A Ward,1 and Donald W Cockcroft1

1Department of Medicine, Division of Respiratory Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
2Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report.