Canadian Respiratory Journal

Canadian Respiratory Journal / 2006 / Article

Review | Open Access

Volume 13 |Article ID 901417 | https://doi.org/10.1155/2006/901417

Hans-Peter Hauber, Susan C Foley, Qutayba Hamid, "Mucin Overproduction in Chronic Inflammatory Lung Disease", Canadian Respiratory Journal, vol. 13, Article ID 901417, 9 pages, 2006. https://doi.org/10.1155/2006/901417

Mucin Overproduction in Chronic Inflammatory Lung Disease

Abstract

Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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