Canadian Respiratory Journal

Canadian Respiratory Journal / 2012 / Article

Case Report | Open Access

Volume 19 |Article ID 258485 |

Dawei Yang, Jennifer M Wilson, Chunxue Bai, John Yee, Pearce G Wilcox, Nasreen Khalil, Robert D Levy, "Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation", Canadian Respiratory Journal, vol. 19, Article ID 258485, 2 pages, 2012.

Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation


Acute exacerbations of interstitial lung disease present as clinical deteriorations, with progressive hypoxemia and parenchymal consolidation not related to infection, heart failure or thromboembolic disease. Following single lung transplantation, patients receive maintenance immunosuppression, which could mitigate the development of acute exacerbations in the native lung. A 66-year-old man with fibrotic, nonspecific interstitial pneumonitis presented with fever, hypoxemia and parenchymal consolidation limited to the native lung four years after single lung transplantation. Investigations were negative for infection, heart failure and thromboembolic disease. The patient worsened over the course of one week despite broad-spectrum antimicrobial therapy, but subsequently improved promptly with augmentation of prednisone dosed to 50 mg daily and addition of N-acetylcysteine. Hence, the patient fulfilled the criteria for a diagnosis of an acute exacerbation of pulmonary fibrosis in his native lung. Clinicians should consider acute exacerbation of parenchymal lung disease of the native lung in the differential diagnosis of progressive respiratory deterioration following single lung transplantation for pulmonary fibrosis.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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