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Canadian Respiratory Journal
Volume 19 (2012), Issue 3, Pages 193-195
Clinico-Pathologic Conferences

Birt-Hogg-Dubé Syndrome: Report of a New Mutation

Habib U Rehman

Regina Qu’Appelle Health Region, Regina, Saskatchewan, Canada

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Birt-Hogg-Dubé syndrome is an autosomal dominant genodermatosis caused by germline mutations in the folliculin gene and characterized by facial papules, pulmonary cysts, kidney tumours and recurrent pneumothoraces. Several distinct mutations in the folliculin gene resulting in a truncated protein have been described. The present report describes a new mutation, which has not been reported in individuals with Birt-Hogg-Dubé syndrome but is of a type predicted to cause disease.