Canadian Respiratory Journal

Canadian Respiratory Journal / 2013 / Article

Original Article | Open Access

Volume 20 |Article ID 131072 |

Ariane Jacob, Catherine Laurin, Kim L Lavoie, Gregory Moullec, Maxine Boudreau, Catherine Lemière, Simon L Bacon, "The Impact Of Body Mass Index On Inpatient- Versus Outpatient-Treated Chronic Obstructive Pulmonary Disease Exacerbations", Canadian Respiratory Journal, vol. 20, Article ID 131072, 6 pages, 2013.

The Impact Of Body Mass Index On Inpatient- Versus Outpatient-Treated Chronic Obstructive Pulmonary Disease Exacerbations


BACKGROUND: Increased body weight has been associated with worse prognoses for many chronic diseases; however, this relationship is less clear in patients with chronic obstructive pulmonary disease (COPD), with underweight patients experiencing higher morbidity than normal or overweight patients.OBJECTIVE: To assess the impact of body mass index (BMI) on the risk for COPD exacerbations.METHODS: The present study included 115 patients with stable COPD (53% women; mean [± SD] age 67±8 years). Height and weight were measured to calculate BMI. Patients were followed for a mean of 1.8±0.8 years to assess the prospective risk of inpatient-treated exacerbations and outpatient-treated exacerbations, all of which were verified by chart review.RESULTS: Cox regression models revealed that underweight patients were at greater risk for inhospital-treated exacerbations (RR 2.93 [95% CI 1.27 to 6.76) relative to normal weight patients. However, overweight (RR 0.59 [95% CI 0.33 to 1.57) and obese (RR 0.99 [95% CI 0.53 to 1.86]) patients did not differ from normal weight patients. All analyses were adjusted for age, sex, length of diagnosis, smoking pack-years, forced expiratory volume in 1 s, and time between recruitment and last exacerbation. BMI did not influence the risk of out-of-hospital exacerbations.CONCLUSIONS: The present study showed that underweight patients were at greater risk for inhospital exacerbations. However, BMI did not appear to be a risk factor for out-of-hospital exacerbations. This suggests that the BMI-exacerbation link may differ according to the nature of the exacerbation, the mechanisms for which are not yet known.

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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