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Canadian Respiratory Journal
Volume 20, Issue 6, Pages 406-408
Clinico-Pathologic Conferences

Diffuse Intrapulmonary Neuroendocrine Cell Hyperplasia

Anna L McGuire,1 Donna E Maziak,1 and Harman S Sekhon2

1Division of Thoracic Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada
2Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diffuse intrapulmonary neuroendocrine cell hyperplasia is a rare, potential precursor lesion to typical pulmonary carcinoid tumours. Fewer than 50 cases have been reported in the literature. Their pathogenesis, clinical significance and management is controversial. A patient who presented with diffuse intrapulmonary neuroendocrine cell hyperplasia associated with a primary typical carcinoid tumour of the lung is reported.