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Canadian Respiratory Journal
Volume 20, Issue 5, Pages 345-350
Original Article

Impact of Obesity on Perinatal Outcomes among Asthmatic Women

Meggie Thuot,1 Marc-André Coursol,1 Sonia Nguyen,1 Vanessa Lacasse-Guay,1 Marie-France Beauchesne,1,2 Anne Fillion,1,3 Amélie Forget,1,3 Fatima-Zohra Kettani,1,3 and Lucie Blais1,2,3

1Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
2Endowment Pharmaceutical Chair AstraZeneca in Respiratory Health, Montréal, Québec, Canada
3Research Centre of Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BACKGROUND: Only one study has investigated the combined effect of maternal asthma and obesity on perinatal outcomes; however, it did not consider small-for-gestational age and large-for-gestational age infants.

OBJECTIVES: To examine the impact of obesity on perinatal outcomes among asthmatic women.

METHODS: A cohort of 1386 pregnancies from asthmatic women was reconstructed using three of Quebec’s administrative databases and a questionnaire. Women were categorized using their prepregnancy body mass index. Underweight, overweight and obese women were compared with normal weight women. The primary outcome was the birth of a small-for-gestational-age infant, defined as a birth weight below the 10th percentile for gestational age and sex. Secondary outcomes were large-for-gestational-age infants (birth weight >90th percentile for gestational age) and preterm birth (<37 weeks’ gestation). Logistic regression models were used to obtain the ORs of having small-for-gestational-age infants, large-for-gestational-age infants and preterm birth as a function of body mass index.

RESULTS: The proportions of underweight, normal weight, overweight and obese women were 10.8%, 53.3%, 19.7% and 16.2%, respectively. Obese asthmatic women were not found to be significantly more at risk for giving birth to small-for-gestational-age infants (OR 0.6 [95% CI 0.4 to 1.1]), large-for-gestational-age infants (OR 1.2 [95% CI 0.7 to 2.2]) or having a preterm delivery (OR 0.7 [95% CI 0.4 to 1.3]) than normal-weight asthmatic women.

CONCLUSIONS: No significant negative interaction between maternal asthma and obesity on adverse perinatal outcomes was observed.