Canadian Respiratory Journal / 2016 / Article / Tab 2

Research Article

Outcomes and Predictors of Mortality for Patients with Acute Leukemia Admitted to the Intensive Care Unit

Table 2

Patient characteristics and outcomes ().


Characteristics at admission
Age, years54 (15)
Female76 (50)
APACHE II score27 (22–33)
SOFA score10 (8–13)
MODS7 (6–10)
Neutropenia (neutrophils < 2.0 × 109/L)84 (74)
Thrombocytopenia (platelets < 50 × 109/L)126 (86)

Admission diagnosis
Sepsis74 (49)
Respiratory46 (31)
Cardiovascular failure15 (10)
Gastrointestinal bleed3 (2)
Neurological dysfunction8 (5)
Other5 (3)

Morbidity in ICU
Sepsis128 (85)
Septic shock87 (58)
Acute respiratory distress syndrome56 (37)
Stroke8 (5)

Treatments in ICU
Mechanical ventilation94 (62)
 NIV alone11 (7)
 NIV followed by intubation15 (10)
 Invasive alone67 (44)
 Total invasive ventilation82 (54)
 Total NIV26 (17)
 High frequency oscillation12 (8)
Tracheostomy8 (5)
Renal replacement therapy23 (15)
 Duration of renal replacement therapy (days)4 (2–6)
Insulin infusion50 (33)

Infections identified in ICU
Microbiologic pathogen identification38 (25)
 Bacterial27 (18)
 Viral8 (5)
 Fungal7 (5)

Medications administered in ICU
Antibiotics144 (95)
Antifungals105 (70)
Chemotherapy41 (27)
Sedatives/opioids104 (69)
 Infusion +/− boluses68 (45)
 Intermittent alone36 (24)
Vasopressors96 (64)
Neuromuscular blockers26 (17)
Steroids47 (31)
Antipsychotics24 (16)

Outcomes
ICU stay, days4 (2–8)
ICU survival94 (62)
30-day survival 74 (49)
90-day survival60 (40)
180-day survival51 (34)
365-day survival37 (25)

Data presented as (%) for categorical variables and mean (SD) or median (IQR) for continuous measures.
Total number of bacterial, viral, and fungal infections is >38 as some patients had more than 1 pathogen identified.
APACHE = acute physiology and chronic health evaluation score, MODS = multiple organ dysfunction score, SOFA = sequential organ failure assessment score, and NIV = noninvasive ventilation.

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