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Canadian Respiratory Journal
Volume 2016, Article ID 3107324, 7 pages
Clinical Study

Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea

1Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3Bumrungrad International Hospital, Bangkok 10110, Thailand

Received 19 February 2016; Revised 2 June 2016; Accepted 12 June 2016

Academic Editor: Akiteru Goto

Copyright © 2016 Promsrisuk Tichanon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and malondialdehyde (MDA) levels in OSA patients. Methods. Thirteen patients with OSA and 13 normal controls were recruited. FeNO and MDA levels were measured in the controls and in OSA patients before and after three months of CPAP therapy. Results. FeNO and MDA levels were higher in the patients compared to the age and gender matched controls (FeNO: 25.9 ± 5.0 versus 17.5 ± 5.9 ppb, ; MDA: 14.6 ± 7.8 versus 2.1 ± 0.3 μmol/L, ). FeNO and MDA levels were lower post-CPAP compared to pre-CPAP (FeNO: 25.9 ± 5.0 versus 17.0 ± 2.3 ppb, ; MDA: 14.6 ± 7.8 versus 10.0 ± 6.4 μmol/L, ). Apnea-hypopnea index (15.9 ± 6.6 versus 4.1 ± 2.1/h, ) and mean arterial pressure () decreased following CPAP treatment. Daytime mean SpO2 () increased. Conclusion. Our study demonstrates that CPAP therapy yields clinical benefits by reducing upper airway inflammation and oxidative stress in OSA patients.