Lesser Toxicities of Belotecan in Patients with Small Cell Lung Cancer: A Retrospective Single-Center Study of Camptothecin Analogs

Table 3

Toxicities (CTCAE version 4.0).

CTCAE toxicity	Belotecan ()				Topotecan ()				All grades; value	Grade 4/5; value
	All grades		Grade 4/5		All grades		Grade 4/5
	Number	%	Number	%	Number	%	Number	%
Hematological toxicity
Anemia	125	66.5	3	1.6	42	64.6	0	0	0.783	0.306
Neutropenia	120	63.8	56	29.8	47	72.3	24	36.9	0.214	0.286
Thrombocytopenia	79	42	12	6.4	40	61.5	14	21.5	0.007	0.001
Nonhematological toxicity
Prurigo nodularis	0	0	0	0	1	1.5	0	0	0.088
Generalized muscle weakness	22	11.7	0	0	10	15.4	0	0	0.441
Anorexia	24	12.8	0	0	9	13.8	0	0	0.824
Constipation	7	3.7	0	0	6	9.2	0	0	0.083
Nausea	15	8	0	0	5	7.7	0	0	0.941
Vomiting	5	2.7	0	0	2	3.1	0	0	0.860
Dyspnea	4	2.1	0	0	4	6.2	1	1.5	0.110	0.088
Lung infection	12	6.4	4	2.1	9	13.8	7	10.8	0.060	0.003
Dizziness	6	3.2	0	0	5	7.7	0	0	0.125
Myalgia	4	2.1	0	0	0	0	0	0	0.236
Sinus tachycardia	0	0	0	0	1	1.5	0	0	0.088
Headache	6	3.2	0	0	7	10.8	0	0	0.017
Cough	1	0.5	0	0	0	0	0	0	0.556
Diarrhea	8	4.3	0	0	6	9.2	0	0	0.130
Skin rash	5	2.7	0	0	2	3.1	0	0	0.860
Intracranial hemorrhage	1	0.5	1	0.5	0	0	0	0	0.556	0.556
TB increased	0	0	0	0	1	1.5	0	0	0.088
AST/ALT increased	3	1.6	1	0.5	3	4.6	3	4.6	0.168	0.023
Abdominal pain	3	1.6	0	0	1	1.5	0	0	0.975
Hiccups	7	3.7	0	0	1	1.5	0	0	0.386
Fever	7	3.7	0	0	1	1.5	0	0	0.386
Confusion	0	0	0	0	1	1.5	0	0	0.088
Hyponatremia	3	1.6	1	0.5	2	3.1	1	1.5	0.460	0.430
Delirium	0	0	0	0	1	1.5	0	0	0.088
Insomnia	2	1.1	0	0	0	0	0	0	0.404
Tremor	1	0.5	0	0	0	0	0	0	0.556
Sore throat	3	1.6	0	0	0	0	0	0	0.306
URI	1	0.5	0	0	0	0	0	0	0.556
Viral hepatitis	1	0.5	1	0.5	0	0	0	0	0.556	0.556
Dyspepsia	0	0	0	0	1	1.5	0	0	0.088
Ileus	0	0	0	0	1	1.5	0	0	0.088
Atrial fibrillation	1	0.5	0	0	0	0	0	0	0.556
Hypokalemia	1	0.5	0	0	0	0	0	0	0.556
Pleural infection	1	0.5	0	0	1	1.5	0	0	0.430

CTCAE: Common Terminology Criteria for Adverse Events, TB: total bilirubin, ALT: alanine transaminase, AST: aspartate transaminase, and URI: upper respiratory tract infection.