Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker

Figure 2

(a) The wedge lung biopsy shows cellular nodules (thick arrows) and an irregular fibrous scar (arrowheads) delimiting a cystically dilated airspace (). Note the flimsy adhesions on the pleural surface, secondary to the pneumothorax (right upper corner, thin arrows)—hematoxylin and eosin stain, 11x. (b) Higher magnification of a cellular nodule reveals numerous histiocytes with folded nuclei (arrows) in an eosinophilic inflammatory background (arrowheads depicting eosinophils)—hematoxylin and eosin stain, 400x. The inset shows strong expression of the immunohistochemical marker CD1a by the histiocytes (brown staining)—CD1a immunohistochemical stain, 110x.

(a)

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