The Clinical Clues of Pulmonary Alveolar Proteinosis: A Report of 11 Cases and Literature Review
Table 2
Clinical examinations of PAP patients.
Patient number
1
2
3
4
5
6
7
8
9
10
11
Laboratory tests
CRP (mg/L)
3.5
23.3
9.5
1.0
4.7
1.0
21.1
2.7
1.6
6.5
5.0
ESR (mm/h)
22
3
12
16
38
16
37
2.0
2.0
34.0
25.0
PaO2 (mmHg)
62.5
48.5
75.5
54.3
59.8
61.2
63.0
81
68.8
62.2
77.4
P(A-a)O2 (mmHg)
50.6
140
21.5
50.8
48.2
36.8
42.3
7.9
34.6
31.7
41.0
LDH (U/L)
206
463
244
310
348
279
268
299
233
301
230
CEA (ng/mL)
4.0
13.3
2.3
5.1
8.2
41.8
5.6
45.0
6.0
6.9
4.0
Cyfra 21-1 (ng/mL)
7.1
33.8
6.9
21.6
12.8
12.7
13.0
NA
NA
NA
NA
NSE (ng/mL)
17.5
24.4
17.6
15.0
19.0
21.5
24.0
21.0
NA
NA
NA
Lung function
FEV1/FVC (%)
94.3
89.9
94.3
91.1
74.2
80.9
88.6
85.7
NA
95.4
100
TLC (% predicted)
65.3
60.4
71.8
46.4
54.2
64.2
78.5
89.6
NA
60.1
65.1
FRC (% predicted)
62.7
60.0
92.2
51.7
42.8
42.8
74.2
112
NA
37.4
46.4
VC (% predicted)
68.0
63.2
73.9
64.8
58.6
89.1
74.4
85.9
NA
62.5
88.9
DLCO (% predicted)
44.0
24.2
40.9
22.4
28.7
56.1
46.6
50.4
NA
36.5
41.7
mMRC score
2
3
1
3
2
0
1
1
3
3
2
Diagnosis method
Surgical biopsy
+
+
−
+
+
NA
NA
NA
NA
NA
NA
Transbronchial biopsy
NA
NA
NA
NA
NA
−
NA
−
−
NA
BALF
+
+
+
NA
NA
+
Clinical course
R
R
SR
R
R
SR
R
R
S
R
R
NA: not available; R: remission; SR: spontaneous remission; S: stabilization; mMRC: modified British medical research council score for shortness of breath.
