Canadian Respiratory Journal

Review Article

Clinical Outcomes Associated with Home Mechanical Ventilation: A Systematic Review

Table 3

Change in SF-36 domains at 12 mo with home ventilation compared to baseline across studies and disease states.
Disease stateStudyPhysical capacityMental capacity
PFRPBPGHPCSViSFREMHMCS
RTDWindisch et al. [7]29NCNCNCNCNC++++NC
Hein et al. [13]8NCNCNCNCNR+NCNC+NR
Nauffal et al. [12]35NC+NCNCNRNC++NCNR
Tsolaki et al. [6]17NRNRNRNR+NRNRNRNR+
NMDWindisch et al. [7]17NCNCNCNCNCNC+NCNCNC
Hein et al. [13]8NCNCNCNCNRNCNCNC+NR
Nauffal et al. [12]27—NCNCNCNRNCNCNCNCNR
Bourke et al. [3]41NCNCNC+NC+NCNC++
Bourke et al. [3]†20NCNCNC+NC+++++
Tsolaki et al. [6]11NRNRNRNRNCNRNRNRNRNC
OHSWindisch et al. [7]9++NC+++NC+++
Tsolaki et al. [6]28NRNRNRNR+NRNRNRNR+
BP, bodily pain; GH, general health; MH, mental health; NC, no change; NMD, neuromuscular disorders; NR, not reported; OHS, obesity hypoventilation syndrome; PF, physical function; RE, role emotional; RP, role physical; RTD, restrictive thoracic diseases; SF, social functioning; Vi, vitality; +, statistically significant improvement; —, statistically significant deterioration.
Amyotrophic lateral sclerosis (ALS) only; †ALS with preserved bulbar function. There were no improvements within any of the domains in the poor bulbar function subgroup.