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Canadian Respiratory Journal
Volume 2016, Article ID 7056035, 4 pages
Clinico-Pathologic Conferences

Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

1Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2G3
2Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada T6G 2G3
3Department of Laboratory-Medicine and Pathology, University of Alberta, Edmonton, AB, Canada T6G 2B7

Received 21 February 2015; Accepted 3 May 2015

Copyright © 2016 Pen Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren’s syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.