Noninvasive Ventilation with Heliox for Respiratory Distress Syndrome in Preterm Infant: A Systematic Review and Meta-Analysis

Table 4

Pooled estimates for Heliox.

Secondary outcomes	Heliox versus standard gas
	Colnaghi et al. 2012		Dani et al. 2013		Li et al. 2014		RR/mean difference (95% CI)	Heterogeneity
	27	24	18	18	19	17		value
Incidence of bronchopulmonary dysplasia	5	3	7	11	0	0	0.81 [0.38–1.73]	0.25	23%
Incidence of patent ductus arteriosus	12	10	16	16	7	5	1.06 [0.79–1.43]	0.82	0%
Incidence of retinopathy of prematurity	1	1	4	5	0	0	0.82 [0.28–2.34]	0.94	0%
Incidence of necrotizing enterocolitis	0	1	2	3	3	1	0.94 [0.30–2.91]	0.45	0%
Hospital stay (days)	52 ± 30	47 ± 33	115 ± 18	109 ± 15	—	—	5.78 [−3.06–14.63]	0.20	0%
Time of noninvasive ventilation (days)	26 ± 37	33 ± 6	—	—	1.6 ± 0.6	2.5 ± 1.0	−0.91 [−1.46–−0.36]	0.001	0%
Incidence of intraventricular hemorrhage	0	0	5	4	0	0	1.25 [0.40–3.91]	Not applicable
Incidence of periventricular leukomalacia	0	0	2	1	0	0	2.00 [0.20–20.15]	Not applicable
Death	0	0	3	2	0	0	1.50 [0.28–7.93]	Not applicable