Table of Contents Author Guidelines Submit a Manuscript
Canadian Respiratory Journal
Volume 2016 (2016), Article ID 9254374, 4 pages
http://dx.doi.org/10.1155/2016/9254374
Case Report

Rapid Growth of Lung Nodules due to Combined Pulmonary Vasculitis, Silicoanthracosis, and Chondrocalcinosis

1Division of Thoracic Surgery, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland
2Department of Rheumatology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland
3Department of Immunology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland
4Division of Pulmonology, University Hospital Zurich, Raemistr. 100, 8091 Zurich, Switzerland

Received 9 October 2015; Accepted 13 June 2016

Academic Editor: Franz Stanzel

Copyright © 2016 Wolfgang Jungraithmayr et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Silicoanthracosis is a pneumoconiosis due to occupational inhalation of silica and carbon dusts. Clinically, it can be associated with vasculitis or rheumatoid arthritis. In association with these diseases, silicoanthracosis can present within the lung with multiple pulmonary nodules which, as a differential diagnosis, can mimic metastatic disease or multiple abscesses. Case Presentation. We present the case of a 62-year old former pit worker with pulmonary nodules, chondrocalcinosis due to calcium pyrophosphate deposition (CPPD), and a history of renal cancer. Within a short period of time, pulmonary nodules grew rapidly. Thoracoscopically, the resected lung specimen revealed silicoanthracosis associated with small-to-medium-size vasculitis in the presence of antineutrophil cytoplasmatic autoantibodies (c-ANCA). Conclusion. Pulmonary silicoanthracotic lesions on the base of ANCA-associated vasculitis and CPPD arthritis can rapidly grow. A mutual correlation between silicoanthracosis, ANCA-associated vasculitis, and CPPD seems possible. Apart from this, consideration of metastatic disease should be obligatory in patients with a history of cancer at the same time being immunosuppressed.