Clinical Utility of Bronchoalveolar Lavage Pepsin in Diagnosis of Gastroesophageal Reflux among Wheezy Infants

Table 5

Sensitivity and specificity of abnormal BAL pepsin levels to diagnose GERD related infantile wheeze compared to the current standard diagnostic tests.

Abnormal pepsin level	Abnormal MII-pH	Reflux esophagitis	LLMI ≥ 100
Sensitivity%	61.7	72	70
Specificity%	55.5	52.9	53
Positive predictive value%	72	44.8	48.3
Negative predictive value%	43.4	78	73.9

GERD, gastroesophageal reflux disease; LLMI, lipid laden macrophage index; MII-pH, multiple channel intraluminal impedance-pH monitoring.