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Canadian Respiratory Journal
Volume 2017 (2017), Article ID 1587865, 13 pages
Review Article

Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis

1Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
2Kyrgyz-Indian Mountain Biomedical Research Center, Bishkek, Kyrgyzstan
3Department of Internal Medicine, University of Giessen and Marburg Lung Center (UGMLC), Justus Liebig University of Giessen, Giessen, Germany

Correspondence should be addressed to Akpay Sarybaev; ur.liam@777ras_ka

Received 29 January 2017; Accepted 21 May 2017; Published 26 July 2017

Academic Editor: R. Andrew Mcivor

Copyright © 2017 Abdirashit Maripov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking. Methods. A comprehensive electronic database (PubMed, Web of Science, and Google Scholar) and reference search up to October 30, 2016, was performed. A systematic review and meta-analysis were performed to assess RV structure and function in OSA patients based on conventional echocardiography and tissue Doppler imaging. Results. Twenty-five studies with 1,503 OSA patients and 796 controls were included in this study. OSA patients exhibited an increase in RV internal diameter (weighted mean difference (WMD) (95% confidence intervals (CIs)) 2.49 (1.62 to 3.37); ) and RV wall thickness (WMD (95% CIs) 0.82 (0.51 to 1.13); ). Furthermore, OSA patients had a significantly elevated RV myocardial performance index (WMD (95% CI) 0.08 (0.06 to 0.10); ), decreased RV S’ (WMD (95% CI) −0.95 (−1.59 to −0.32); ), tricuspid annular plane systolic excursion (WMD (95% CI) −1.76 (−2.73 to −0.78); ), and RV fractional area change (WMD (95% CI) −3.16 (−5.60 to −0.73); ). Conclusion. OSA patients display RV dilatation, increased wall thickening, and altered RV function.