Table of Contents Author Guidelines Submit a Manuscript
Canadian Respiratory Journal
Volume 2017, Article ID 9064046, 10 pages
https://doi.org/10.1155/2017/9064046
Research Article

The Role of Serotonin Transporter in Human Lung Development and in Neonatal Lung Disorders

1Department of Pathology & Immunology, Texas Children’s Hospital, Baylor College of Medicine, 6621 Fannin St. MC-1195, Houston, TX 77030, USA
2Department of Pediatrics, Baylor College of Medicine, 6621 Fannin St. MC-1195, Houston, TX 77030, USA
3Department of Pathology, Magee Women’s Hospital, UPMC, Pittsburgh, PA 15213, USA
4Department of Pathology and Laboratory Medicine, Children’s Hospital Colorado, University School of Medicine of Colorado, 13123 East 16th Avenue, P.O. Box 120, Aurora, CO 80045, USA

Correspondence should be addressed to C. Galambos; gro.odarolocsnerdlihc@sobmalag.abasc

Received 6 October 2016; Revised 8 December 2016; Accepted 10 January 2017; Published 20 February 2017

Academic Editor: Elie El Agha

Copyright © 2017 E. C. C. Castro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. K. Weir and J. T. Reeves, Pulmonary Vascular Physiology and Pathophysiology, Dekker, New York, NY, USA, 1989.
  2. D. L. Levin, M. A. Heymann, J. A. Kitterman et al., “Persistent pulmonary hypertension of the newborn,” Journal of Pediatrics, vol. 89, pp. 626–633, 1976. View at Google Scholar
  3. N. B. Bishop, P. Stankiewicz, and R. H. Steinhorn, “Alveolar capillary dysplasia,” American Journal of Respiratory and Critical Care Medicine, vol. 184, no. 2, pp. 172–179, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Sen, N. Thakur, D. W. Stockton, C. Langston, and B. A. Bejjani, “Expanding the phenotype of alveolar capillary dysplasia (ACD),” Journal of Pediatrics, vol. 145, no. 5, pp. 646–651, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Stankiewicz, P. Sen, S. S. Bhatt et al., “Genomic and Genic Deletions of the FOX Gene Cluster on 16q24.1 and Inactivating Mutations of FOXF1 Cause Alveolar Capillary Dysplasia and Other Malformations,” American Journal of Human Genetics, vol. 84, no. 6, pp. 780–791, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Gien, G. J. Seedorf, V. Balasubramaniam, N. Markham, and S. H. Abman, “Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor-nitric oxide signaling,” American Journal of Respiratory and Critical Care Medicine, vol. 176, no. 11, pp. 1146–1153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. A. F. Junod, “Metabolism, production, and release of hormones and mediators in the lung,” The American Review of Respiratory Disease, vol. 112, no. 1, pp. 93–108, 1975. View at Google Scholar · View at Scopus
  8. B. R. Pitt, “Metabolic functions of the lung and systemic vasoregulation,” Federation Proceedings, vol. 43, no. 11, pp. 2574–2577, 1984. View at Google Scholar · View at Scopus
  9. J. M. Strum and A. F. Junod, “Radioautographic demonstration of 5-hydroxytryptamine- 3 H uptake by pulmonary endothelial cells,” The Journal of Cell Biology, vol. 54, no. 3, pp. 456–467, 1972. View at Publisher · View at Google Scholar · View at Scopus
  10. S. I. Said, “Metabolic functions of the pulmonary circulation,” Circulation Research, vol. 50, no. 3, pp. 325–333, 1982. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Wojciak-Stothard and S. G. Haworth, “Perinatal changes in pulmonary vascular endothelial function,” Pharmacology and Therapeutics, vol. 109, no. 1-2, pp. 78–91, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. C. N. Gillis and J. A. Roth, “Pulmonary disposition of circulating vasoactive hormones,” Biochemical Pharmacology, vol. 25, no. 23, pp. 2547–2553, 1976. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Al-Ubaidi and Y. S. Bakhle, “Metabolism of vasoactive hormones in human isolated lung,” Clinical Science, vol. 58, no. 1, pp. 45–51, 1980. View at Publisher · View at Google Scholar · View at Scopus
  14. C. N. Gillis, L. H. Cronau, S. Mandel, and G. L. Hammond, “Indicator dilution measurement of 5-hydroxytryptamine clearance by human lung,” Journal of Applied Physiology, vol. 46, pp. 1178–1183, 1979. View at Google Scholar
  15. S. Ramamoorthy, A. L. Bauman, K. R. Moore et al., “Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 6, pp. 2542–2546, 1993. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Nocito, F. Dahm, W. Jochum et al., “Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis,” Gastroenterology, vol. 133, no. 2, pp. 608–618, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Marzioni, S. Glaser, H. Francis et al., “Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin,” Gastroenterology, vol. 128, no. 1, pp. 121–137, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Nocito, P. Georgiev, F. Dahm et al., “Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice,” Hepatology, vol. 45, no. 2, pp. 369–376, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Nocito, F. Dahm, W. Jochum et al., “Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts,” Cancer Research, vol. 68, no. 13, pp. 5152–5158, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. G. M. Mawe, M. D. Coates, and P. L. Moses, “Review article: intestinal serotonin signalling in irritable bowel syndrome,” Alimentary Pharmacology and Therapeutics, vol. 23, no. 8, pp. 1067–1076, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. D. Gershon and J. Tack, “The serotonin signaling system: from basic understanding to drug development for functional GI disorders,” Gastroenterology, vol. 132, no. 1, pp. 397–414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. D. Chambers, S. Hernandez-Diaz, L. J. Van Marter et al., “Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn,” The New England Journal of Medicine, vol. 354, no. 6, pp. 579–587, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. C. D. Chambers, K. A. Johnson, L. M. Dick, R. J. Felix, and K. L. Jones, “Birth outcomes in pregnant women taking fluoxetine,” New England Journal of Medicine, vol. 335, no. 14, pp. 1010–1015, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Fornaro, D. Li, J. Pan, and J. Belik, “Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat,” American Journal of Respiratory and Critical Care Medicine, vol. 176, no. 10, pp. 1035–1040, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Delaney, J. Gien, T. R. Grover, G. Roe, and S. H. Abman, “Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 301, no. 6, pp. L937–L944, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. C. Walsh-Sukys, J. E. Tyson, L. L. Wright et al., “Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes,” Pediatrics, vol. 105, no. 1, pp. 14–20, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. D. L. Murphy, A. Lerner, G. Rudnick, and K.-P. Lesch, “Serotonin transporter: gene, genetic disorders, and pharmacogenetics,” Molecular Interventions, vol. 4, no. 2, pp. 109–123, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. D. L. Murphy and K.-P. Lesch, “Targeting the murine serotonin transporter: insights into human neurobiology,” Nature Reviews Neuroscience, vol. 9, no. 2, pp. 85–96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Colucci, C. Blandizzi, M. Bellini, N. Ghisu, M. Tonini, and M. Del Tacca, “The genetics of the serotonin transporter and irritable bowel syndrome,” Trends in Molecular Medicine, vol. 14, no. 7, pp. 295–304, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Carrasco, M. A. Cruz, A. Dominguez, V. Gallardo, P. Miguel, and C. González, “The expression and activity of monoamine oxidase A, but not of the serotonin transporter, is decreased in human placenta from pre-eclamptic pregnancies,” Life Sciences, vol. 67, no. 24, pp. 2961–2969, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Ni and S. W. Watts, “5-Hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT),” Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 7, pp. 575–583, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Eddahibi, N. Hanoun, L. Lanfumey et al., “Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene,” The Journal of Clinical Investigation, vol. 105, no. 11, pp. 1555–1562, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Eddahibi, M. Humbert, E. Fadel et al., “Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension,” The Journal of Clinical Investigation, vol. 108, no. 8, pp. 1141–1150, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Eddahibi and S. Adnot, “Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis,” Respiratory Research, vol. 3, article no. 9, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Eddahibi, A. Chaouat, N. Morrell et al., “Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease,” Circulation, vol. 108, no. 15, pp. 1839–1844, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. C. H. Huang and S. L. Santangelo, “Autism and serotonin transporter gene polymorphisms: a systematic review and meta-analysis,” American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 147, no. 6, pp. 903–913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Zhang, M. Xu, J. Xia, and R.-Y. Qin, “Association between serotonin transporter (SERT) gene polymorphism and idiopathic pulmonary arterial hypertension: a meta-analysis and review of the literature,” Metabolism: Clinical and Experimental, vol. 62, no. 12, pp. 1867–1875, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. M. R. MacLean, “Pulmonary hypertension and the serotonin hypothesis: where are we now?” International Journal of Clinical Practice. Supplement, vol. 156, pp. 27–31, 2007. View at Google Scholar
  39. M. R. MacLean and Y. Dempsie, “The serotonin hypothesis of pulmonary hypertension revisited,” Advances in Experimental Medicine and Biology, vol. 661, pp. 309–322, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Kimura and G. H. Deutsch, “Key mechanisms of early lung development,” Pediatric and Developmental Pathology, vol. 10, no. 5, pp. 335–347, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Antao, M. Samuel, E. Kiely, L. Spitz, and M. Malone, “Congenital alveolar capillary dysplasia and associated gastrointestinal anomalies,” Fetal and Pediatric Pathology, vol. 25, no. 3, pp. 137–145, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. B. P. Chelliah, D. Brown, M. Cohen, A. J. Talleyrand, and S. Shen-Schwarz, “Alveolar capillary dysplasia—a cause of persistent pulmonary hypertension unresponsive to a second course of extracorporeal membrane oxygenation,” Pediatrics, vol. 96, no. 6, pp. 1159–1161, 1995. View at Google Scholar · View at Scopus
  43. R. Rabah and J. M. Poulik, “Congenital alveolar capillary dysplasia with misalignment of pulmonary veins associated with hypoplastic left heart syndrome,” Pediatric and Developmental Pathology, vol. 4, no. 2, pp. 167–174, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Booij, J. De Jong, K. De Bruin, R. Knol, M. M. L. De Win, and B. L. F. Van Eck-Smit, “Quantification of striatal dopamine transporters with123I-FP-CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double-blind, placebo-controlled, crossover study in healthy control subjects,” Journal of Nuclear Medicine, vol. 48, no. 3, pp. 359–366, 2007. View at Google Scholar · View at Scopus
  45. K.-J. Lin, C.-Y. Liu, S.-P. Wey et al., “Brain SPECT imaging and whole-body biodistribution with [123I]ADAM—a serotonin transporter radiotracer in healthy human subjects,” Nuclear Medicine and Biology, vol. 33, no. 2, pp. 193–202, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. A. B. Newberg, K. Plössl, P. D. Mozley et al., “Biodistribution and imaging with 123I-ADAM: a serotonin transporter imaging agent,” Journal of Nuclear Medicine, vol. 45, no. 5, pp. 834–841, 2004. View at Google Scholar · View at Scopus
  47. I. Makkonen, R. Riikonen, H. Kokki, M. M. Airaksinen, and J. T. Kuikka, “Serotonin and dopamine transporter binding in children with autism determined by SPECT,” Developmental Medicine and Child Neurology, vol. 50, no. 8, pp. 593–597, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Hesse, P. Brust, P. Mäding et al., “Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 39, no. 6, pp. 1001–1011, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Brust, J. Zessin, H. Kuwabara et al., “Positron emission tomography imaging of the serotonin transporter in the pig brain using [11C](+)-McN5652 and S-([18F]fluoromethyl)-(+)-McN5652,” Synapse, vol. 47, no. 2, pp. 143–151, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. P. Brust, R. Hinz, H. Kuwabara et al., “In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652,” Neuropsychopharmacology, vol. 28, no. 11, pp. 2010–2019, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Haase, A.-M. Killian, F. Magnani, and C. Williams, “Regulation of the serotonin transporter by interacting proteins,” Biochemical Society Transactions, vol. 29, no. 6, pp. 722–728, 2001. View at Publisher · View at Google Scholar · View at Scopus
  52. C. Galambos, Y.-S. Ng, A. Ali et al., “Defective pulmonary development in the absence of heparin-binding vascular endothelial growth factor isoforms,” American Journal of Respiratory Cell and Molecular Biology, vol. 27, no. 2, pp. 194–203, 2002. View at Publisher · View at Google Scholar · View at Scopus
  53. R. N. N. Han and D. J. Stewart, “Defective lung vascular development in endothelial nitric oxide synthase-deficient mice,” Trends in Cardiovascular Medicine, vol. 16, no. 1, pp. 29–34, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. M. J. Connolly and P. I. Aaronson, “Key role of the RhoA/Rho kinase system in pulmonary hypertension,” Pulmonary Pharmacology and Therapeutics, vol. 24, no. 1, pp. 1–14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. D. J. Samuvel, L. D. Jayanthi, N. R. Bhat, and S. Ramamoorthy, “A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression,” Journal of Neuroscience, vol. 25, no. 1, pp. 29–41, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Eddahibi, N. Morrell, M.-P. d'Ortho, R. Naeije, and S. Adnot, “Pathobiology of pulmonary arterial hypertension,” European Respiratory Journal, vol. 20, no. 6, pp. 1559–1572, 2002. View at Publisher · View at Google Scholar · View at Scopus