Particle size determines location of drug deposition. Aerodynamic particle size determines deposition patterns across the human respiratory tract. Simulations were performed using Multiple-Path Particle Dosimetry software [95
]. Each simulated particle size represents one simulation. The Yeh/Schum five-lobe model [96
] with uniform expansion was applied. The inhalation characteristics used for the simulation were an inhaled volume of 2 L, an inhalation flow rate of 60 L/min, and a breath-holding time of 8 seconds. These simulations do not account for the influence of an inhalation device on deposition.