Adrenal Insufficiency in Cystic Fibrosis: A Rare Phenomenon?
Table 2
Paraclinical characteristics of patients with CF according to their adrenal function .
Sufficient
Insufficient
value
Pulmonary function test
FEV1 (% pred)
44.6 (22.0–120.0)
52.9 (27.5–82.6)
0.509
FVC (% pred)
69.9 (32.8–113.8)
72.6 (51.0–97.8)
0.885
RV (% pred)
177.0 (80.0–414.0)
197.5 (126.0–406.0)
0.271
Biochemistry
Fasting cortisol (nmol/L)
421.0 (191.0–954.0)
146.0 (12.0–335.0)
≤0.001
Cortisol (nmol/L)
1 μg functional cortrosyn test (n)
33
28
0 minutes
388.0 (113.0–852.0)
139.5 (10.0–382.0)
≤0.001
30 minutes
628.0 (502.0–1079.0)
354.0 (25.0–491.0)
≤0.001
60 minutes
510.0 (210.0–902.0)
300.5 (23.0–457.0)
≤0.001
250 μg functional cortrosyn test (n)
2
2
0 minutes
426.5 (407.0–446.0)
158.5 (26.0–291.0)
NA
30 minutes
637.5 (606.0–669.0)
325.5 (179.0–472.0)
NA
60 minutes
678.0 (664.0–692.0)
309.5 (238.0–381.0)
NA
Hematology
WBC (109/L)
7.6 (4.1–10.8)
8.0 (2.55–17.5)
0.294
Medication
Systemic corticosteroids (% yes)
0
42.4
≤0.001
Duration (months)
—
18.0 (0.25–74.0)
—
Inhaled corticosteroids (% yes)
66.7
93.9
0.005
Chronic inhaled antibiotic (% yes)
100.0
78.8
0.005
Medical history
Number of hospitalizations (2 years prior to diagnosis)
2.0 (0–8.0)
2.0 (0–11.0)
0.593
Number of intravenous antibiotic treatments (2 years prior to diagnosis)
3.0 (0–8.0)
3.0 (0–11.0)
0.565
Colonization/microbiology
Non-TB mycobacteria (% yes)
8.6
3.0
0.335
Staphylococcus aureus (% yes)
31.4
39.4
0.495
Pseudomonas aeruginosa (% yes)
77.1
81.8
0.636
Aspergillus and fungi (% yes)
17.1
48.5
0.006
Stenotrophomonas maltophilia (% yes)
25.0
30.3
0.625
Others (% yes)
19.4
12.1
0.410
FEV1, forced expiratory volume-one second; FVC, forced vital capacity; RV, residual volume; WBC, white blood cell count; TB, tuberculous; NA, not applicable. Median and interval range are shown. value < 0.05 represents Mann-Whitney Student’s t-test.
