The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model

Figure 1

The production of P16 and P21 in the airway epithelium of COPD patients. (a) Micrographs of histological sections of the COPD patients’ airway showed the loss of epithelial integrity, apparent deciduous epithelial cells (black arrow), cilia lodging (white arrow), and submucosal and bronchial surrounding fibrous tissue hyperplasia (triangle) by HE staining (HE, 400x). (b) The expression of P16 and P21 in the airway epithelium of patients with COPD and control subjects were detected by IHC (200x). (c) Semiquantitative analysis of P16 and P21 expression in COPD and control groups was conducted by the optical density (OD). (d, e) The expression of P16 and P21 in the airway epithelium of patients with COPD and control subjects were determined by western blotting. .

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