Research Article
Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia
Table 1
Patients’ characteristics.
| | Characteristics | Overall patients (A) | Having an acute exacerbation (B) | Not having an acute exacerbation (C) | value (B vs. C) |
| | Total number | 28 | 14 | 14 | | | Age (years) | 73 (64–79) | 76 (66–80) | 70 (63–76) | 0.131 | | Male sex, N (%) | 17 (61) | 9 (64) | 8 (57) | 0.699 | | Parameters | | | | | | Serum hemeoxygenase-1 (ng/mL) | 41.7 (23.9–56.9) | 53.5 (46.2–88.5) | 24.1 (17.1–31.1) | <0.001 | | Serum lactate dehydrogenase (U/L) | 320.0 (224.8–435.5) | 370.0 (274.5–463.5) | 240.5 (190.5–336.5) | 0.017 | | PaO2/FiO2 ratio | 280.5 (204.1–357.7) | 239.0 (178.4–321.2) | 341.9 (229.8–398.6) | 0.046 | | Serum surfactant protein-A (ng/mL) | 76.8 (55.6–118.0) | 75.6 (61.2–124.0) | 77.9 (50.6–101.0) | 0.325 | | Serum surfactant protein-D (ng/mL) | 221.0 (122.0–307.0) | 231 (113.5–332.5) | 193.5 (126.3–290.8) | 0.544 | | Serum Krebs von den Lungen-6 (U/mL) | 1005.0 (616.0–2152.0) | 1056 (720.0–2454.5) | 977.0 (354.8–2049.3) | 0.482 | | Ground glass opacity score | 7.0 (4.3–9.8) | 8.0 (6.8–11.8) | 5.0 (3.0–7.5) | 0.024 | | Honeycomb score | 6.0 (0.3–8.8) | 8.0 (3.0–8.3) | 1.0 (0.0–9.5) | 0.156 | | Diagnosis, N (%) | | | | | | Idiopathic pulmonary fibrosis | 16 (57) | 10 (71) | 6 (43) | 0.127 | | Nonidiopathic pulmonary fibrosis | 12 (43) | 4 (29) | 8 (57) | 0.127 | | Outcome | | | | | | Hospital death, N (%) | 7 (25) | 6 (43) | 1 (7) | 0.023 |
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Values are reported as median with 25–75 percentiles or %, unless otherwise indicated.
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