Study of Clinical Characteristics and Cytokine Profiles of Asthmatic Children with Rhinovirus Infection during Acute Asthma Exacerbation at National Hospital of Pediatrics
Table 2
Clinical and biological characteristics of asthmatic children classified by RV infection.
Characteristics
Asthma with RV−
Asthma with RV+
Subjects, (%)
52 (45.2)
63 (54.8)
NS
Age
<2 years, (%)
13 (25.0)
11 (17.5)
NS
Mean ± SD (months)
16 ± 4
18 ± 5
NS
2–5 years, (%)
19 (36.5)
33 (52.4)
NS
Mean ± SD (months)
41 ± 12
42 ± 13
NS
>5 years, (%)
20 (38.5)
19 (30.2)
NS
Mean ± SD (months)
95 ± 20
110 ± 31
NS
Male/female (ratio)
2.0
1.7
NS
Atopy
Eczema (%)
47.5
52.5
NS
Allergic rhinitis (%)
62.0
70.9
NS
Seasonal allergy (%)
95.9
94.8
NS
Others, (%)
8.1
14.8
NS
Second-hand smoking (%)
18.3
17.2
NS
Domestic animals† (%)
4.1
3.6
NS
PAS
Mild, (%)
14 (26.9)
5 (7.9)
<0.01
Moderate, (%)
16 (30.7)
22 (34.9)
NS
Severe, (%)
22 (42.4)
36 (57.2)
<0.05
Length of hospitalization
1–3 days, (%)
14 (27.5)
21 (33.3)
NS
Mean ± SD (days)
2.8 ± 0.4
2.7 ± 0.6
NS
>3–5 days, (%)
27 (52.9)
27 (42.8)
NS
Mean ± SD (days)
4.4 ± 0.5
4.5 ± 0.5
NS
>5 days, (%)
10 (19.6)
15 (23.8)
NS
Mean ± SD (days)
8.0 ± 2.0
7.4 ± 1.9
NS
Leukocytes
Increasing, (%)
36 (69.2)
58 (92.1)
<0.01
Mean ± SD
16023 ± 4532
15822 ± 4517
NS
Not increasing, (%)
16 (30.8)
5 (7.9)
<0.01
Mean ± SD
7518 ± 1716
6146 ± 3867
NS
Polymorphonuclear leukocytes
Increasing, (%)
31 (59.6)
48 (76.2)
<0.05
Percentage ± SD
67.6 ± 12.8
72.2 ± 12.4
NS
Not increasing, (%)
21 (40.4)
15 (23.8)
<0.05
Percentage ± SD
43.8 ± 11.1
42.3 ± 15.5
NS
Eosinophils
Increasing, (%)
14 (26.9)
20 (33.3)
NS
Percentage ± SD
7.7 ± 3.4
6.3 ± 2.6
NS
Not increasing, (%)
38 (73.1)
40 (66.7)
NS
Percentage ± SD
1.2 ± 1.1
1.2 ± 1.1
NS
†Dog or cat. RV: rhinovirus; RV+: positive RV infection; RV−: negative RV infection. PAS: pediatric asthma score consisted of five components as described in footnote of Table 1.
