ELISA Development for Serum Hemeoxygenase-1 and Its Application to Patients with Acute Respiratory Distress Syndrome
Table 3
Clinical characteristics of patients with ARDS.
Characteristics
Overall cases ()
Survivors ()
Nonsurvivors ()
values, survivors versus nonsurvivors
Age, years
68.5 (62.0–75.0)
68.5 (56.5–75.0)
67.5 (63.0–76.0)
0.741
Male sex, (%)
16 (73)
6 (50)
10 (100)
0.009
Body mass index
21.1 (18.6–23.1)
21.5 (20.3–23.4)
20.5 (18.3–23.1)
0.410
APACHE II score
25.5 (18.0–31.0)
23.0 (17.0–31.0)
26.5 (19.0–29.0)
0.644
Severity of ARDS, (%)
0.548
Mild
7 (32)
5 (42)
2 (20)
Moderate
11 (50)
5 (42)
6 (60)
Severe
4 (18)
2 (17)
2 (20)
Etiology of ARDS, (%)
0.145
Infection
14 (64)
6 (42)
8 (80)
Other causes
8 (36)
6 (58)
2 (20)
Respiratory parameters
D0 PaO2/FIO2 ratio
165 (118–262)
176 (131–302)
141.5 (105.0–185.0)
0.291
D7 PaO2/FIO2 ratio
198 (123–280)
260 (183–365)
140.5 (97.5–212.5)
0.019
D0 LIS
2.5 (2.0–2.8)
2.3 (1.6–2.5)
2.8 (2.5–3.5)
0.015
D7 LIS
2.3 (1.8–2.8)
2.0 (1.5–2.3)
3.0 (2.5–3.3)
0.008
Blood parameters
D0 HO-1, ng/mL
75.4 (39.1–111.6)
61.7 (28.7–96.2)
100.5 (69.0–167.2)
0.027
D7 HO-1, ng/mL
74.5 (22.1–130.6)
32.5 (18.4–88.4)
123.8 (72.2–148.4)
0.008
D0 LDH, U/L
307 (242–437)
307 (253–448)
305 (237–437)
0.843
D7 LDH, U/L
326 (263–448)
326 (270–473)
329 (245–418)
0.847
D0 CRP, mg/dL
14.8 (9.7–24.1)
12.8 (9.2–26.6)
16.5 (11.4–20.3)
0.921
D7 CRP, mg/dL
6.9 (2.5–13.8)
7.7 (1.9–13.6)
5.7 (4.9–16.6)
0.642
Outcomes
Mechanical ventilation, days
11.5 (7.0–21.0)
9.5 (7.5–17.0)
14.0 (5.0–24.0)
0.668
Length ICU stay, days
13.0 (9.0–26.0)
11.5 (10.0–27.0)
14.0 (5.0–26.0)
0.741
Values are reported as median with 25–75th percentiles or %, unless otherwise indicated. Two of the 10 nonsurvivors died within 7 days. APACHE, acute physiology and chronic health evaluation; ARDS, acute respiratory distress syndrome; LIS, lung injury score; HO-1, hemeoxygenase-1; LDH, lactate dehydrogenase; CRP, C-reactive protein.
