Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea

Table 1

Demographic characteristics, sleep profiles, and blood measurements of the OSA and control groups.

	Control group (n = 21)	OSA group (n = 36)	value
Age (years)	39.33 ± 9.40	38.81 ± 7.84	0.821
Gender (male/female)^a	14/7	29/7	0.195
Waist-to-hip ratio	0.87 ± 0.07	0.92 ± 0.08	0.020
BMI (kg/m^2)	26.60 ± 5.31	28.28 ± 4.74	0.219
AHI (events/h)	2.47 ± 1.18	35.37 ± 20.16	<0.001
ODI (events/h)	1.73 ± 0.98	31.27 ± 18.57	<0.001
AI (events/h)	13.24 ± 7.65	36.91 ± 19.85	<0.001
Lowest SPO2 (%)	90.70 ± 1.09	79.58 ± 8.52	<0.001
Mean SPO2 (%)	93.53 ± 1.05	90.26 ± 2.92	<0.001
Duration of SPO2 < 90% (%)	0.50 ± 1.57	19.86 ± 8.76	<0.001
TST (min)	317.48 ± 42.53	328.44 ± 39.90	0.343
REM sleep (%)	13.52 ± 3.23	11.21 ± 3.25	0.012
NREM sleep (%)	86.48 ± 3.32	88.79 ± 3.25	0.012
Sestrin2 (ng/mL)	2.06 ± 1.76	4.16 ± 2.37	0.001
TG (mmol/L)	1.48 ± 0.46	1.82 ± 1.17	0.224
TC (mmol/L)	4.19 ± 0.83	4.32 ± 0.66	0.532
LDL (mmol/L)	2.30 ± 0.65	2.47 ± 0.58	0.325
HDL (mmol/L)	1.05 ± 0.33	1.00 ± 0.25	0.560
FBG (mmol/L)	4.36 ± 0.56	4.56 ± 0.58	0.213
ESS (scores)	6.76 ± 3.19	12.11 ± 4.34	<0.001

Values are indicated as mean ± standard deviation. OSA, obstructive sleep apnea; BMI, body mass index; AHI, apnea/hypopnea index; ODI, oxygen desaturation index; AI, arousal index; SPO₂, pulse oxygen saturation; TST, total sleep time; REM, rapid eye movement; NREM, nonrapid eye movement; TG, triglycerides; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; FBG, fasting blood glucose; ESS, Epworth Sleepiness Score. ^aValues are indicated as numbers. , the results are statistically significant.