Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea

Table 2

Demographic characteristics, sleep profiles, and blood measurements of the OSA subgroups and the control group.

	Control (n = 21)	Mild (n = 7)	Moderate (n = 10)	Severe (n = 19)
Age (years)	39.33 ± 9.40	34.85 ± 8.09	39.40 ± 7.86	39.94 ± 9.40
Waist-to-hip ratio	0.87 ± 0.07	0.88 ± 0.05	0.93 ± 0.06	0.93 ± 0.09
BMI (kg/m^2)	26.60 ± 5.31	29.62 ± 6.82	27.45 ± 2.52	28.21 ± 4.72
AHI (events/h)	2.47 ± 1.18	11.10 ± 2.66	22.29 ± 5.07	51.20 ± 13.66
ODI (events/h)	1.73 ± 0.98	9.32 ± 2.37	19.76 ± 5.46	45.42 ± 13.48
AI (events/h)	13.24 ± 7.65	16.88 ± 9.72	22.09 ± 4.17	52.08 ± 14.33
Lowest SPO2 (%)	90.70 ± 1.09	87.29 ± 3.30	83.60 ± 4.25	74.63 ± 8.40
Mean SPO2 (%)	93.53 ± 1.05	92.24 ± 2.01	91.67 ± 1.92	88.79 ± 2.91
Duration of SPO2 < 90% (%)	0.50 ± 1.57	19.77 ± 9.59	14.46 ± 6.15	22.73 ± 8.64
TST (min)	317.48 ± 42.53	311.43 ± 21.64	341.00 ± 46.05	328.11 ± 40.97
REM sleep (%)	13.52 ± 3.23	12.33 ± 3.58	10.30 ± 2.76	11.28 ± 3.39
NREM sleep (%)	86.48 ± 3.32	87.67 ± 3.58	89.70 ± 2.77	88.72 ± 3.39
Sestrin2 (ng/mL)	2.06 ± 1.76	2.63 ± 1.66	3.09 ± 1.77	5.28 ± 2.36
TG (mmol/L)	1.48 ± 0.46	2.09 ± 1.02	1.62 ± 0.78	1.83 ± 1.39
TC (mmol/L)	4.19 ± 0.83	4.80 ± 0.38	4.09 ± 0.52	4.26 ± 0.74
LDL (mmol/L)	2.30 ± 0.65	2.85 ± 0.42	2.31 ± 0.47	2.40 ± 0.64
HDL (mmol/L)	1.17 ± 0.34	1.00 ± 0.25	1.00 ± 0.20	1.01 ± 0.29
FBG (mmol/L)	4.36 ± 0.56	4.54 ± 0.75	4.51 ± 0.40	4.60 ± 0.62
ESS (scores)	6.76 ± 3.19	10.86 ± 2.91	10.80 ± 4.5	13.26 ± 4.51

Values are indicated as mean ± standard deviation. OSA, obstructive sleep apnea; BMI, body mass index; AHI, apnea/hypopnea index; ODI, oxygen desaturation index; AI, arousal index; SPO₂, pulse oxygen saturation; TST, total sleep time; REM, rapid eye movement; NREM, nonrapid eye movement; TG, triglycerides; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; FBG, fasting blood glucose; ESS, Epworth Sleepiness Score. vs. the control.