Upregulation of Potassium Voltage-Gated Channel Subfamily J Member 2 Levels in the Lungs of Patients with Idiopathic Pulmonary Fibrosis

Figure 2

KCNJ2 protein concentrations in BAL fluids and ROC analysis. (a) KCNJ2 protein was detected in 18 of 30 NCs, 79 of 84 IPF patients, 7 of 9 NSIP patients, 5 of 8 HP patients, and 9 of 10 sarcoidosis patients. The data are presented as median values with 25% and 75% quartiles. (b) ROC curve of the KCNJ2 protein levels in IPF patients and NCs. A cut-off value of 0.636 ng/mL had an AUC of 0.893, a specificity of 90.0%, and a sensitivity of 83.3% for differentiating IPF patients from NCs. (c) ROC curve of the KCNJ2 protein level in patients with IPF and those with other interstitial lung diseases.

(a)

(b)

(c)