The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population

Table 3

Genotypic and allelic frequencies of miR-146a rs2910164 and miR-155 rs767649 polymorphisms in non-small-cell lung cancer (NSCLC) and control subjects.

Polymorphism	Lung cancer, n = 165 subjects (%)	Control, n = 147subjects (%)	OR (95% CI)	value
miR-146a Rs2910164
Allele
G	219 (66.36%)	222 (75.55%)	1 (reference)
C	111 (33.64%)	72 (24.45%)	1.56 (1.10–2.21)	0.012
Co-dominant
GG	69 (41.8%)	81 (55.1%)	1 (reference)
GC	81 (49.1%)	60 (40.8%)	1.58 (0.99–2.51)	0.051
CC	15 (9.1%)	6 (4.1%)	2.93 (1.07–7.9)	0.034
Dominant
GG	69 (41.8%)	81 (55.1%)	1 (reference)
GC + CC	96 (58.2%)	66 (44.9%)	1.7 (1.09–2.67)	0.019
Recessive
GG + GC	150 (90.9%)	141 (95.9%)	1 (reference)
CC	15 (9.1%)	6 (4.1%)	2.35 (0.88–6.22)	0.085
miR-155 Rs767649
Allele
T	290 (87.87%)	242 (82.3%)	1 (reference)
A	40 (12.13%)	52 (17.6%)	0.64 (0.41–1.00)	0.051
Co-dominant
TT	131 (79.3%)	102 (69.3%)	1 (reference)
AT	28 (16.9%)	38 (25.8%)	0.57 (0.33–0.99)	0.048
AA	6 (3.6%)	7 (4.7%)	0.66 (0.21–2.04)	0.47
Dominant
TT	131 (79.3%)	102 (69.3%)	1 (reference)
AA + AT	34 (20.6%)	45 (30.6%)	0.58 (0.35–0.98)	0.043
Recessive
AT + TT	159 (96.3%)	140 (95.2%)	1 (reference)
AA	6 (3.6%)	7 (4.7%)	0.75 (0.24–2.29)	0.62

OR = odds ratio.