The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population

Table 4

The association between SNPs and the risk of NSCLC stratified by smoking.

SNP	Genotype	Nonsmokers (n = 117)				Smokers (n = 195)
		Control (%)	Case (%)	OR (95% CI)	P value	Control (%)	Case (%)	OR (95% CI)	value
miR-146a rs2910164	GG	29 (53.7%)	25 (39.7%)	1		52 (56%)	44 (43%)	1
	GC	25 (46.3%)	33 (52.3%)	1.53 (0.72–3.22)	0.26	35 (38%)	48 (47%)	1.62 (0.89–2.93)	0.11
	CC	0 (0%)	5 (8.0%)	12.7 (0.67–241)	0.09	6 (6%)	10 (10%)	1.96 (0.66–5.85)	0.22
miR-155 rs767649	TT	42 (77.7%)	48 (76.1%)	1		60 (64.5%)	83 (81.3%)	1
	TA	12 (22.3%)	12 (19.0%)	0.87 (0.35–2.15)	0.77	26 (27.9%)	16 (15.6%)	0.44 (0.21–0.90)	0.024
	AA	0 (0%)	3 (4.8%)	6.13 (0.30–122)	0.23	7 (7.5%)	3 (2.9%)	0.30 (0.07–1.24)	0.099