Ward-Based Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Unrelated to Chronic Obstructive Pulmonary Disease

Table 1

Participant baseline characteristics.

Characteristics	Median (IQR) OR n (%)
	Total n = 479	Obesity-related AHRFn = 188	Non-obesity-related AHRF n = 291
Age (years)	73 [62–81]	69 [60–75]	76 [65.75–84]	<0.001
Male	192 (40.1)	66 (35.1)	126 (43.3)	<0.001
Female	287 (59.9)	122 (64.9)	165 (56.7)	0.011
Survival to discharge	384 (80.2)	175 (93.1)	209 (71.8)	0.083
In-hospital mortality	95 (19.8)	13 (6.9)	82 (28.2)	<0.001
Pre-NIV pH	7.27 [7.21–7.31]	7.27 [7.23–7.31]	7.26 [7.20–7.31]	0.042
Pre-NIV pH thresholds
pH > 7.15	61 (12.7)	16 (8.5)	45 (15.5)	<0.001
pH 7.15–7.25	138 (28.8)	50 (26.6)	88 (30.2)	0.001
pH < 7.25	280 (58.5)	122 (64.9)	158 (54.3)	0.031
NIV failure	101 (21.1)	15 (8.0)	86 (29.6)	<0.001
Subgroup (BHH)
Duration of NIV (days)	5 [3–9]	6 [4–10]	4 [2–9]	0.015
RF to NIV (minutes)	123 [63.5–302.5]	123 [63.5–302.5]	122 [60.0–316.0]	0.692
Domiciliary NIV	44 (23.4)	27 (14.4)	17 (5.8)	0.132

Obesity-related AHRF patients due to obesity hypoventilation syndrome; IQR, interquartile range; BHH, Birmingham Heartlands Hospital; NIV, noninvasive ventilation; RF, respiratory failure; AHRF: acute hypercapnic respiratory failure.