Research Article
Ward-Based Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Unrelated to Chronic Obstructive Pulmonary Disease
Table 1
Participant baseline characteristics.
| Characteristics | Median (IQR) OR n (%) | | Total n = 479 | Obesity-related AHRFn = 188 | Non-obesity-related AHRF n = 291 |
| Age (years) | 73 [62–81] | 69 [60–75] | 76 [65.75–84] | <0.001 | Male | 192 (40.1) | 66 (35.1) | 126 (43.3) | <0.001 | Female | 287 (59.9) | 122 (64.9) | 165 (56.7) | 0.011 | Survival to discharge | 384 (80.2) | 175 (93.1) | 209 (71.8) | 0.083 | In-hospital mortality | 95 (19.8) | 13 (6.9) | 82 (28.2) | <0.001 | Pre-NIV pH | 7.27 [7.21–7.31] | 7.27 [7.23–7.31] | 7.26 [7.20–7.31] | 0.042 | Pre-NIV pH thresholds | pH > 7.15 | 61 (12.7) | 16 (8.5) | 45 (15.5) | <0.001 | pH 7.15–7.25 | 138 (28.8) | 50 (26.6) | 88 (30.2) | 0.001 | pH < 7.25 | 280 (58.5) | 122 (64.9) | 158 (54.3) | 0.031 | NIV failure | 101 (21.1) | 15 (8.0) | 86 (29.6) | <0.001 |
| Subgroup (BHH) | Duration of NIV (days) | 5 [3–9] | 6 [4–10] | 4 [2–9] | 0.015 | RF to NIV (minutes) | 123 [63.5–302.5] | 123 [63.5–302.5] | 122 [60.0–316.0] | 0.692 | Domiciliary NIV | 44 (23.4) | 27 (14.4) | 17 (5.8) | 0.132 |
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Obesity-related AHRF patients due to obesity hypoventilation syndrome; IQR, interquartile range; BHH, Birmingham Heartlands Hospital; NIV, noninvasive ventilation; RF, respiratory failure; AHRF: acute hypercapnic respiratory failure. |