Ward-Based Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure Unrelated to Chronic Obstructive Pulmonary Disease
Table 3
Multivariable logistic regression demonstrating the predictors of in-hospital mortality.
Variable
Odds ratio
Total non-COPD AHRF
Pre-NIV pH > 7.25
pH > 7.15
2.223a (1.130–4.375)
0.021
pH 7.15–7.25
1.865a (1.091–3.187)
0.023
Pre-NIV pH
0.004 (0.000–0.062)
<0.001
Pneumonia on admission
5.313b (2.326–12.131)
<0.001
Bronchiectasis on admission
4.236b (1.680–10.679)
0.002
NMD on admission
4.038b (1.888–8.636)
0.003
Fluid overload on admission
3.735b (1.556–8.966)
0.021
Age
1.034 (1.017–1.051)
>0.001
Subgroup (BHH): domiciliary NIV
0.065 (0.009–0.488)
0.008
Subgroup: obesity-related AHRF
Pre-NIV pH > 7.25
pH > 7.15
7.800a (1.843–33.013)
0.005
pH 7.15–7.25
2.035a (0.523–7.915)
0.305
Age
1.030 (0.981–1.082)
0.231
Subgroup: non-obesity-related AHRF
Pre-NIV pH > 7.25
pH > 7.15
4.538a (1.694–9.354)
0.002
pH 7.15–7.25
1.843a (1.038–3.272)
0.037
Age
1.030 (1.010–1.050)
0.005
aThe odds ratio is against the reference group: pH < 7.25, bThe odds ratio is against the reference group: obesity-related AHRF. The pre-NIV pH was analysed as the continuous variable; COPD: chronic obstructive pulmonary disease; AHRF: acute hypercapnic respiratory failure; NIV: noninvasive ventilation; NMD: neuromuscular disease; BHH: Birmingham Heartlands Hospital.