LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway

Figure 3

(a–e) Effect of LASP1 on the pathological features of TGF-β1-treated A549 and SK-MES-1. (a) The representative images of transwell assays showed the inhibitory or enhanced effect of LASP1 silence or overexpression under TGF-β1-induced invasion, respectively. (b) The quantification showed the relative permeability compared to the cell alone group without TGF-β1 treatment. (c) The representative images of wound healing assays showed the inhibitory or enhanced effect of LASP1 silence or overexpression under TGF-β1-induced migration. (d) The quantification showed the relative migration. (e) LASP1 silence or overexpression had an inhibitory or enhanced effect on lung cancer cell’s proliferation until to 72 h under TGF-β1 treatment, respectively. Data were shown as mean ± SD, n = 3. , , and vs. the cell alone group without TGF-β1 treatment, and , , and vs. the TGF-β1-treated noninfection group (TGF-β1).

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