Research Article

LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway

Figure 4

(a-b) LASP1 regulated EMT-related markers expression in A549 (a) and SK-MES-1 (b) cell lines under TGF-β1 treatment. After 48 h coinfection with TGF-β1 accompanying LASP1 knockdown or overexpression, cell lysates were detected by western blot for EMT-related marker expression, including N-cadherin, vimentin, and E-cadherin. GAPDH was used as reference control. Data were shown as mean ± SD, n = 3. , , and vs. the cell alone group without TGF-β1 treatment, and , , and vs. the TGF-β1-treated noninfection group (TGF-β1).
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