Research Article

Nomogram for Predicting the Relationship between the Extent of Visceral Pleural Invasion and Survival in Non-Small-Cell Lung Cancer

Table 1

Characteristics of NSCLC patients with the different subdivision levels of VPI.

VariablesAll patients N = (87,045)Training cohort N = (60,933)Validation cohort N = (26,112)
N (%)N (%)N (%)

Sex
 Female42,199 (48.5)29,550 (48.5)12,649 (48.4)
 Male44,846 (51.5)31,383 (51.5)13,463 (51.6)

Age(years)
 <6015,510 (17.8)10,813 (17.7)4,697 (18.0)
 ≥6071,535 (82.2)50,120 (82.3)21,415 (82.0)

Race
 Black9,583 (11.0)6,758 (11.1)2,825 (10.8)
 White71,259 (81.9)49,896 (81.9)21,363 (81.8)
 Others6,203 (7.1)4,279 (7.0)1,924 (7.4)

Marital
 Married46,595 (53.5)32,584 (53.5)14,011 (53.7)
 Divorced10,766 (12.4)7,584 (12.4)3,182 (12.1)
 Single11,420 (13.1)7,946 (13.0)3,474 (13.3)
 Widowed14,727 (16.9)10,330 (17.0)4,397 (16.8)
 Unknown3,537 (4.1)2,489 (4.1)1,048 (4.0)

Histology
 AC49,530 (56.9)34,766 (57.1)14,764 (56.5)
 BAC5,366 (6.1)3,736 (6.1)1,630 (6.2)
 LCC1,710 (2.0)1,202 (2.0)508 (2.0)
 SC30,439 (35.0)21,229 (34.8)9,210 (35.3)

Grade
 I11,539 (13.3)8,065 (13.2)3,474 (13.3)
 II35,660 (41.0)24,918 (40.9)10,742 (41.1)
 III38,508 (44.2)26,979 (44.3)11,529 (44.2)
 IV1,338 (1.5)971 (1.6)367 (1.4)

T stage
T129,605 (34.0)20,790 (34.1)8,815 (33.76)
T225,870 (29.7)18,047 (29.6)7,823 (29.96)
T316,523 (19.0)11,607 (19.1)4,916 (18.83)
T414,972 (17.2)10,432 (17.1)4,540 (17.39)

N stage
N050,120 (57.6)35,040 (57.5)15,080 (57.8)
N18,122 (9.4)5,736 (9.4)2,476 (9.5)
N221,968 (25.2)15,446 (25.4)6,522 (25.0)
N36,745 (7.8)4,711 (7.7)2,034 (7.7)

M stage
M063,034 (72.4)44,062 (72.3)18,972 (72.7)
M124,011 (27.6)16,871 (27.7)7,140 (27.3)

Pleural
 PLX45,747 (52.6)31,976 (52.5)13,771 (52.7)
34,690 (39.9)24,389 (40.0)10,301 (39.4)
2,977 (3.4)2,064 (3.4)913 (3.5)
2,529 (2.9)1,763 (2.9)766 (3.0)
1,102 (1.3)741 (1.2)361 (1.4)

Note: AC: adenocarcinoma; BAC: bronchioalveolar carcinoma; LCC: large-cell carcinoma; SC: squamous cell carcinoma.