Research Article

Impact of HACOR Score on Noninvasive Ventilation Failure in Non-COPD Patients with Acute-on-Chronic Respiratory Failure

Table 1

Baseline data for patients who experienced successful NIV and NIV failure.

Overall cohort, N = 148Successful NIV, N = 129NIV failure, N = 19

Age, years64 ± 1664 ± 1667 ± 110.49
Sex, male83 (56%)71 (55%)12 (63%)0.62
APACHE II score16 ± 515 ± 420 ± 7<0.01

Diagnosis
 Sleep apnea-hypopnea syndrome52 (35%)48 (37%)4 (21%)0.12
 Chronic thoracic sequelae34 (23%)28 (22%)6 (32%)
 Bronchiectasis31 (21%)25 (19%)6 (32%)
 Chest wall deformity14 (10%)14 (11%)0 (0%)
 Obesity-hypoventilation syndrome5 (3%)3 (2%)2 (11%)
 Others12 (8%)11 (9%)1 (5%)

Underlying disease
 Hypertension68 (46%)62 (48%)6 (32%)0.22
 Chronic heart disease29 (20%)25 (19%)4 (21%)>0.99
 Diabetes mellitus28 (19%)23 (18%)5 (26%)0.36
 Chronic renal failure11 (7%)9 (7%)2 (11%)0.63
 Liver cirrhosis4 (3%)2 (2%)2 (11%)0.08
 Duration of NIV (h)96 (42–143)103 (50–166)29 (3–77)<0.01
 Length of stay in the ICU (days)5.8 (3.7–10.8)5.5 (3.7–10.4)6.6 (3.4–13.2)0.79
 Length of stay in the hospital (days)11.8 (6.8–19.0)11.8 (6.8–18.9)12.1 (7.6–21.8)0.88
 Hospital mortality14 (10%)4 (3%)10 (53%)<0.01

NIV, noninvasive ventilation; APACHE II, Acute Physiology and Chronic Health Evaluation II; ICU, intensive care unit.