Clinical Manifestations of Pulmonary Mucormycosis in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A 21-Case Series Report and Literature Review

Figure 1

Radiographic signs and histological characteristics of PM in recipients of allo-HSCT. (a–d) The dynamic evolution of imaging during the treatment of the same patient. (a) A normal chest CT scan 20 days before infection. (b, c) Right anterior upper lobe lesions on day 7 and day 13 rapidly progressing with clinical deterioration. (d) The exudation around the lesion was significantly reduced after 3 days of application of L-AMB. A reversed halo sign was seen both in the initial stage of infection and after antifungal treatment (arrowhead). (e, f) Another patient’s chest CT image. The lesion invaded the right bronchus. (g, h) Biopsy of the infected lung tissue showing ribbon-like aseptate hyphae with wide-angle branching accompanied by evidence of tissue damage under the microscope (HE stain (a), GMS stain (b), and 400x).

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