Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis

Figure 1

Normalization of gene expression and cluster analysis and PCA analysis for each sample. (a) Normalization of gene expression for GSE53408 data. (b) Normalization of gene expression for GSE113439 data. Abscissa shows sample lists, and ordinates show the gene expression value (log2 transformed). Blue bars represent the data before normalization, and red bars represent the normalized data. (c) Cluster analysis and PCA analysis for each sample of GSE53408 data. (d) Cluster analysis and PCA analysis for each sample of GSE113439 data. The PAH group data and the normal group data are readily distinguished. Abbreviations: IPAH, idiopathic pulmonary arterial hypertension; CTDPAH, connective tissue disease-associated PAH; CHDPAH, congenital heart disease-associated PAH.

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