Prognostic Role of Chronic Obstructive Pulmonary Disease and Asthma Physiology Score for in-Hospital and 1-year Mortality in Patients with Acute Exacerbations of COPD

Table 5

Assessing the influence of CAPS levels on 1-year mortality by Cox regression analyses.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P Value	HR (95% CI)	P Value
Age (per increase of 10-year)	2.69 (1.54–4.68)	<0.001	3.08 (1.43–6.62)	0.004
Sex (female vs male)	1.45 (0.59–3.57)	0.415
Smoking status never smoker vs current/ever smoker	1.67 (0.64–4.38)	0.296
BMI (per increase of 1 point)	1.01 (0.92–1.11)	0.876
COPD stage (per increase to next stage)	1.45 (0.94–2.23)	0.089	2.52 (1.28–4.95)	0.007
Exacerbations during preceding year (yes vs no)	1.23 (0.60–2.56)	0.572
CHF (yes vs no)	4.84 (2.31–10.14)	<0.001	3.70 (1.52–9.02)	0.004
RD (yes vs no)	1.90 (0.66–5.45)	0.235
CAPS (≥21 vs. < 21 points)	4.07 (1.97–8.44)	<0.001	2.24 (0.90–5.53)	0.082
Percentage of neutrophils (<80 vs. ≥ 80%)	1.98 (0.92–4.28)	0.083	0.82 (0.33–2.05)	0.672
Lymphocyte count (<1.1 vs.≥ 1.1×109/L)	1.23 (0.57–2.68)	0.598
PH
(PH < 7.35 vs. 7.35 ≤ PH ≤ 7.45)	0.77 (0.18–3.24)	0.718
(PH > 7.45 vs. 7.35 ≤ PH ≤ 7.45)	1.34 (0.40–4.45)	0.634
PaO2 (≥60 vs. <60 mmHg)	2.77 (0.96–8.05)	0.061	1.22 (0.38–3.93)	0.742
PaCO2 (≥50 vs. <50 mmHg)	1.50 (0.65–3.45)	0.341

CHF, congestive heart failure; RD, renal dysfunction; HR, hazard ratio.