Performance of the CORB (Confusion, Oxygenation, Respiratory Rate, and Blood Pressure) Scale for the Prediction of Clinical Outcomes in Pneumonia

Table 3

Performance of CORB and CURB-65 scores for mortality, vasopressor support, and IMV outcomes.

	S	E	PPV	NPV	LR+	LR−	AUC	CI 95%(inf-sup)	value
In-hospital mortality
CORB ≥2 (SpO2 ≤90%)	49,1%	78,1%	28,5%	89,6%	2,24	0,65	0,660	(0.623–0.697)	<0.001
CORB ≥2 (SpO2/FiO2 <300)	72,5%	61,4%	25,0%	92,6%	1,88	0,45	0,706	(0.67–0.741)	<0.001
CURB-65 ≥ 2	85,3%	45,2%	21,7%	94,6%	1,56	0,32	0,727	(0.695–0.759)	<0.001
30-day mortality
CORB ≥2 (SpO2 ≤90%)	21,8%	52,5%	8,3%	77,4%	0,46	1,49	0,657	(0.621–0.692)	<0.001
CORB ≥2 (SpO2/FiO2 <300)	38,3%	28,6%	9,5%	70,3%	0,54	2,16	0,698	(0.664–0.733)	<0.001
CURB-65 ≥ 2	54,5%	14,5%	11,1%	61,8%	0,64	3,15	0,726	(0.695–0.756)	<0.001
Vasopressor support
CORB ≥2 (SpO2 ≤90%)	46,3%	76,2%	25,7%	88,9%	1,95	0,70	0,635	(0.589–0.681)	<0.001
CORB ≥2 (SpO2/FiO2 <300)	37,9%	87,6%	35,1%	88,8%	3,05	0,71	0,702	(0.66–0.745)	<0.001
CURB-65 ≥ 2	71,8%	41,9%	18,0%	89,3%	1,24	0,67	0,608	(0.562–0.654)	<0.001
IMV
CORB ≥2 (SpO2 ≤90%)	43,0%	76,2%	24,3%	88,3%	1,81	0,75	0,637	(0.589–0.685)	<0.001
CORB ≥2 (SpO2/FiO2 <300)	37,7%	88,0%	35,8%	88,8%	3,15	0,71	0,700	(0.654–0.746)	<0.001
CURB-65 ≥ 2	71,0%	42,1%	17,9%	89,1%	1,23	0,69	0,587	(0.538–0.637)	<0.001
Composite outcome (in-hospital mortality/IMV requirement/vasopressor requirement)
CORB ≥2 (SpO2 ≤90%)	45,2%	42,1%	28,2%	89,1%	2,21	0,69	0,64	(0,618–0,681))	0,016
CORB ≥2 (SpO2/FiO2 <300)	36,4%	91,3%	42,6%	89,0%	4,18	0,70	0,71	(0,688–0,748)	0,015
CURB-65 ≥ 2	77,9%	45,9%	20,4%	92,1%	1,44	0,48	0,68	(0,651–0,712)	0,016

S: sensibility. E: specificity. PPV: positive predictive value. NPV: negative predictive value. LR+: positive likelihood ratio. LR−: negative likelihood ratio. AUC: area under the curve of receiver operating characteristics. CI: confidence interval. CORB: confusion (new onset or deterioration of preexisting condition), oxygen saturation ≤90%, respiratory rate ≥30/min, and systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg. CURB-65: confusion, urea nitrogen >7 mmol/L (19 mg/dL), respiratory rate ≥30/min, systolic blood pressure <90 mmHg or diastolic blood pressure ≤60 mmHg, and age ≥65 years. FiO₂: fraction of inspired oxygen. SpO₂: oxygen saturation by pulse oximetry. SpO₂/FiO₂: oxygen saturation by pulse oximetry/fraction of inspired oxygen ratio.