Research Article
Assessing the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Stage I Non-Small-Cell Lung Cancer with Complete Resection
Table 3
Univariate and multivariate Cox regression analyses of PFS and OS.
| Variables | PFS | OS | Univariate | Multivariate | Univariate | Multivariate | HR (95% CI) | | HR (95% CI) | | HR (95% CI) | | HR (95% CI) | |
| Age (≥65 vs.<65) | 0.782 (0.483–1.268) | 0.319 | | | 2.258 (1.011–5.040) | 0.047 | 0.621 (0189–2.035) | 0.431 | Gender (male vs. female) | 1.944 (1.181–3.200) | 0.009 | 1.984 (0.927–4.246) | 0.078 | 0.420 (0.188–0.937) | 0.011 | 2.722 (0.568–13.045) | 0.210 | Smoking history (cur/for vs. never) | 1.741 (1.078–2.813) | 0.023 | 1.129 (0.515–2.475) | 0.762 | 2.382 (1.067–5.318) | 0.034 | 1.075 (0.267–4.331) | 0.919 | Histologic type (squamous vs. adenocarcinoma) | 0.261 (0.113–0.607) | 0.002 | 1.131 (0.489–2.620) | 0.532 | 0.164 (0.069–0.391) | 0.001 | 0.281 (0.059–1.337) | 0.111 | Stage (IB vs. IA1 + IA2) | 2.067 (1.191–3.586) | 0.010 | 1.590 (0.826–3.058) | 0.349 | 2.463 (1.001–6.063) | 0.041 | 1.928 (0.530–7.009) | 0.319 | Differentiation (poor vs. well) | 1.513 (1.148–1.993) | 0.002 | 0.669 (0.313–1.429) | 0.578 | 3.918 (1.542–9.956) | 0.004 | 1.122 (0.308–4.087) | 0.862 | Lymphovascular invasion (present vs. absent) | 1.948 (1.138–3.333) | 0.015 | 2.100 (1.090–4.043) | 0.027 | 1.105 (0.413–2.961) | 0.842 | | | Visceral pleural invasion (absent vs. present) | 0.969 (0.480–1.957) | 0.930 | | | 0.556 (0.131–2.364) | 0.427 | | | Tumor location (upper vs. lower) | 1.476 (0.851–2.562) | 0.166 | | | 3.220 (1.391–7.453) | 0.006 | 2.114 (0.765–5.843) | 0.149 | Chemotherapy (no vs. yes) | 1.754 (0.955–3.222) | 0.070 | | | 1.681 (0.720–3.929) | 0.230 | | | CEA (high vs. low) | 3.895 (2.358–6.435) | 0.001 | 2.953 (1.637–5.329) | 0.001 | 5.004 (2.206–11.351) | 0.001 | 3.995 (1.377–11.593) | 0.011 | CYFRA211 (high vs. low) | 2.160 (1.306–3.571) | 0.003 | 1.795 (0.879–3.664) | 0.108 | 2.192 (0.929–5.172) | 0.073 | | | RDW-SD (high vs. low) | 3.003 (1.863–4.841) | 0.001 | 2.570 (1.458–4.528) | 0.001 | 5.110 (2.234–11.686) | 0.001 | 4.638 (1.6614–13.326) | 0.004 | LDH (high vs. low) | 2.009 (1.236–3.26 | 0.005 | 1.622 (0.904–2.912) | 0.105 | 2.385 (1.069–5.325) | 0.034 | 1.810 (0.634–5.168) | 0.268 | NLR (high vs. low) | 1.612 (0.929–2.800) | 0.090 | | | 4.839 (2.172–10.780) | 0.001 | 3.208 (1.243–8.277) | 0.016 |
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