Predictive Value of Adenoviral Load for Bronchial Mucus Plugs Formation in Children with Adenovirus Pneumonia

Table 2

Comparison of the clinical characteristics of patients with single AdV infection in the BMP and control group.

Variables	BMP group (n = 64)	Control group (n = 124)	Value
Characteristics
Gender (male)	36 (56.25)	87 (70.16)	0.057
Age (M(P25–P75))/(months)	26 (12–48)	20 (10–36)	0.31
Age group (months)
<23	27 (42.19)	69 (55.65)	0.08
24–60	30 (46.88)	46 (37.10)	0.19
>60	6 (9.38)	9 (7.26)	0.61
Length of hospitalization (M(P25–P75))/d	10 (7–15)	8 (6–12)	0.044
Allergic constitution (n (%))	13 (20.31)	6 (4.84)	0.001
Signs and symptoms
Dyspnea (n (%))	30 (46.88)	45 (36.29)	0.16
Heat range (M(P25–P75))/d	12 (9–17)	8 (6–12)	<0.001
Tachycardia (n (%))	42 (65.63)	66 (53.23)	0.103
Lung rales (n (%))	58 (90.63)	107 (86.29)	0.39
Lung wheezing (n (%))	21 (32.81)	30 (24.19)	0.208
Hepatomegaly (n (%))	28 (43.75)	37 (29.84)	0.057
Poor spirit (n (%))	26 (40.63)	30 (24.19)	0.02
Complication (n (%))	32 (50)	37 (29.84)	0.007
Disease severity
Mild (n (%))	39 (60.94)	102 (82.26)	0.001
Severe (n (%))	25 (39.06)	22 (17.74)	0.001
Admission to PICU (n (%))	22 (34.38)	20 (16.13)	0.004
Ventilator-assisted ventilation (n (%))	9 (14.06)	6 (4.84)	0.027
Bronchiolitis obliterans (n (%))	9 (14.06)	5 (4.03)	0.013
Laboratory characteristics
WBC (M(P25–P75))/×10^9 L^−1	8.83 (6.36–13.35)	10.28 (7.49–14.24)	0.48
N% (M(P25–P75))/%	39.8 (34.65–58.7)	41.3 (27.5–59.5)	0.98
Hb (M(P25–P75))/g·L^−1	112 (108–115)	115 (108–122)	0.57
PLT (M(P25–P75))/×10^9 L^−1	280 (199–411)	350 (253–499)	0.26
CRP (M(P25–P75))/mg·L^−1	12 (3–26)	6 (3–15)	0.36
LDH (M(P25–P75))/U·L^−1	407 (327–612)	367 (272–430)	0.13
DD (M(P25–P75))/mg·L^−1	1.58 (0.77–2.68)	0.7 (0.4–1.54)	0.002
CK-MB (M(P25–P75))/ng·mL^−1	29 (22–42)	30 (21–42)	0.82
ALT (M(P25–P75))/U·L^−1	24 (14–42)	20 (14–33)	0.57
AdV load from BALF (x ± s), log10 copies/mL	7.14 ± 1.73	5.59 ± 1.84	<0.001
Humoral immunity (M(P25–P75), %)
IgG (M(P25–P75))/g·L^−1	7.85 (6.41–9.95)	8.04 (6.4–9.84)	0.39
IgA (M(P25–P75))/g·L^−1	0.93 (0.58–1.2)	0.77 (0.44–1.21)	0.68
IgM (M(P25–P75))/g·L^−1	1.04 (0.67–1.45)	0.95 (0.76–1.33)	0.18
Cellular immunity (M(P25–P75), %)
CD3+	58.14 (47.4–64.8)	52.63 (45.54–71.13)	0.76
CD3+CD4+	27 (20.56–36.08)	27 (22.28–35.58)	0.5
CD3+CD8+	20 (18.96–27.38)	22.52 (18.71–29.03)	0.81
Radiological characteristics
Lung consolidation (n (%))	40 (62.5)	86 (69.35)	0.343
Pleural effusion (n (%))	4 (6.25)	6 (4.84)	0.683
Treat time (M(P25–P75))/day of course
Corticosteroids	7 (6–11)	7 (6–10)	0.69
Gamma globulin	7 (5–8)	7 (4–11)	0.62
Tracheoscopy intervention	9 (6–12)	9 (5–12)	0.73

BMP, bronchial mucus plug; AdV, Adenovirus; WBC, leukocyte; N%, percentage of neutrophils; Hb, hemoglobin; PLT, platelet; CRP, C-reactive protein; LDH, lactate dehydrogenase; DD, D-dimer; CK-MB, creatine kinase isoenzyme; ALT, gluten laboratory data of alanine transaminase; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M.