Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence

Figure 1

MAD2L1 was upregulated in IPF lungs and the bleomycin-induced mouse lungs. (a) mRNA level of MAD2L1 in lung tissues from patients with IPF and healthy subjects. (b) Representative images of MAD2L1 immunohistochemical staining in sections of lung tissue from patients with IPF and healthy subjects. The boxed regions are shown at higher magnification in the lower panels. (c) mRNA expression of MAD2L1 in bleomycin- and saline-treated mice as determined by qRT-PCR analysis. (d) Protein expression of MAD2L1 in bleomycin- and saline-treated mice as determined by WB analysis. The data are shown as the mean ± SEM, n ≥ 3 per group. ; ; . (e) Representative images of MAD2L1 immunohistochemical staining in sections of lung tissue from bleomycin-treated mice and saline-treated control mice. The boxed regions are shown at higher magnification in the lower panels.

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