Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence

Figure 5

MAD2L1 inhibition increased ROS production in A549 cells. (a) ROS was measured using DCFH-DA surface fluorescence in A549 cells transfected with MAD2L1 siRNA or control siRNA. (b) Quantification of intensity of the DCFH-DA surface fluorescence. (c) ROS was measured using DCFH-DA surface fluorescence in A549 cells treated with M2I-1 or DMSO (control). (d) Quantification of intensity of the DCFH-DA surface fluorescence. ; .

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